Studies of Non-Protective Autophagy Provide Evidence that Recovery from Therapy-Induced Senescence is Independent of Early Autophagy
Identifieur interne : 000044 ( Main/Exploration ); précédent : 000043; suivant : 000045Studies of Non-Protective Autophagy Provide Evidence that Recovery from Therapy-Induced Senescence is Independent of Early Autophagy
Auteurs : Tareq Saleh ; Liliya Tyutyunyk-Massey [États-Unis] ; Nipa H. Patel [États-Unis] ; Emmanuel K. Cudjoe ; Moureq Alotaibi ; David A. Gewirtz [États-Unis]Source :
- International Journal of Molecular Sciences [ 1422-0067 ] ; 2020.
Abstract
Autophagy and senescence, predominant responses that may dictate cell fate after chemotherapy or radiation, often occur in tandem. Cells in states of senescence and/or autophagy are frequently growth arrested. We have previously reported that tumor cells induced into senescence by therapy can re-emerge from the growth-arrested state, a phenomenon termed proliferative recovery. The current work shows that, while tumor cells collaterally induced into senescence and autophagy by etoposide, doxorubicin, or radiation undergo proliferative recovery, neither pharmacological nor genetic inhibition of early autophagy alter the extent of senescence or the ability of cells to recover from senescence. These findings confirm and extend our previous observations, essentially dissociating senescence from autophagy, and further indicate that re-emergence from senescence does not appear to be facilitated by or dependent on autophagy. Our results also provide additional evidence for the promotion of the non-protective form of autophagy by both chemotherapeutic drugs and radiation, which may complicate current efforts to inhibit autophagy for therapeutic benefit.
Url:
DOI: 10.3390/ijms21041427
PubMed: 32093197
PubMed Central: 7073138
Affiliations:
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Gewirtz</name><affiliation><nlm:aff id="af2-ijms-21-01427">Massey Cancer Center, Goodwin Research Laboratories, Virginia Commonwealth University, Richmond, VA 23298, USA;<email>tyutyunykmals@vcu.edu</email> (L.T.-M.);<email>patelnh3@vcu.edu</email> (N.H.P.)</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af3-ijms-21-01427">Department of Pharmacology and Toxicology and Medicine, Virginia Commonwealth University, Richmond, VA 23298, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pharmacology and Toxicology and Medicine, Virginia Commonwealth University, Richmond, VA 23298</wicri:regionArea><wicri:noRegion>VA 23298</wicri:noRegion></affiliation></author></analytic><series><title level="j">International Journal of Molecular Sciences</title><idno type="eISSN">1422-0067</idno><imprint><date when="2020">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Autophagy and senescence, predominant responses that may dictate cell fate after chemotherapy or radiation, often occur in tandem. Cells in states of senescence and/or autophagy are frequently growth arrested. We have previously reported that tumor cells induced into senescence by therapy can re-emerge from the growth-arrested state, a phenomenon termed proliferative recovery. The current work shows that, while tumor cells collaterally induced into senescence and autophagy by etoposide, doxorubicin, or radiation undergo proliferative recovery, neither pharmacological nor genetic inhibition of early autophagy alter the extent of senescence or the ability of cells to recover from senescence. These findings confirm and extend our previous observations, essentially dissociating senescence from autophagy, and further indicate that re-emergence from senescence does not appear to be facilitated by or dependent on autophagy. 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Cudjoe</name><name sortKey="Saleh, Tareq" sort="Saleh, Tareq" uniqKey="Saleh T" first="Tareq" last="Saleh">Tareq Saleh</name></noCountry><country name="États-Unis"><noRegion><name sortKey="Tyutyunyk Massey, Liliya" sort="Tyutyunyk Massey, Liliya" uniqKey="Tyutyunyk Massey L" first="Liliya" last="Tyutyunyk-Massey">Liliya Tyutyunyk-Massey</name></noRegion><name sortKey="A Gewirtz, David" sort="A Gewirtz, David" uniqKey="A Gewirtz D" first="David" last="A. Gewirtz">David A. Gewirtz</name><name sortKey="H Patel, Nipa" sort="H Patel, Nipa" uniqKey="H Patel N" first="Nipa" last="H. Patel">Nipa H. Patel</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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